Fig. 2: Scheme of miR-205 regulation. | Cell Death & Disease

Fig. 2: Scheme of miR-205 regulation.

From: Unveiling the ups and downs of miR-205 in physiology and cancer: transcriptional and post-transcriptional mechanisms

Fig. 2

At the transcriptional level, miR-205 is regulated by transcription factors (TF) or epigenetic modifications (indicated by stars). At the post-transcriptional level, alternative splicing of MIR205HG primary transcript gives origin to miR-205 compatible and non-compatible transcripts (1). Drosha masks the splicing site between MIR205HG exons 4 and 5.1, favoring the use of an alternative exon (exon 5.2) and the excision of pre-miR-205, which is then processed by Dicer into miRNA duplex (2). miR-205 bioavailability is regulated by several cytoplasmic lncRNAs acting as miRNA sponges (3).

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