Fig. 3: Effects of RR-11a on wound healing and scar formation after MI. | Cell Death & Disease

Fig. 3: Effects of RR-11a on wound healing and scar formation after MI.

From: Legumain is a predictor of all-cause mortality and potential therapeutic target in acute myocardial infarction

Fig. 3

A Legumain activity in plasma and cardiac tissue collected from saline-treated or RR-11a-treated mice at 3 and 14 days, n = 4. B Relative mRNA levels of α-SMA, collagen I and III in the cardiac tissue collected from saline-treated or RR-11a-treated mice at 7 and 14 days, n = 4. C–D Protein levels of α-SMA and collagen I in hearts from saline-treated and RR-11a-treated mice, with or without MI on day 7, n = 4. E–F Gelatine zymogram analysis of MMP-2 activity in cardiac tissues from saline-treated and RR-11a-treated mice on day 3 after sham operation or after induction of MI, n = 3. G–I Representative immunofluorescence images of α-SMA (G), collagen I (H), and collagen III (I) in cardiac tissues from saline-treated or RR-11a-treated mice on day 30 post-MI, n = 4. Scale bars: white, 50 μm; yellow, 20 μm. *P < 0.05 vs. sham mice; #P < 0.05 vs. saline-treated MI mice. Col1a1: collagens I; Col3a1: collagens III.

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