Fig. 5: Effects of RR-11a on survival rate, wall thickness, and myocardial fibrosis. | Cell Death & Disease

Fig. 5: Effects of RR-11a on survival rate, wall thickness, and myocardial fibrosis.

From: Legumain is a predictor of all-cause mortality and potential therapeutic target in acute myocardial infarction

Fig. 5

A Kaplan–Meier survival analysis at different time points after MI. B Representative ventricular rupture 3 days after the induction of MI. C Incidence of cardiac rupture in saline-treated and RR-11a-treated mice on day 30 post-MI. D Representative Masson’s trichrome staining of hearts collected from saline-treated and RR-11a-treated mice on day 30 post-MI or sham operation. E–F Quantitative analysis of infarct size (E), and wall thickness (F) using Masson’s trichrome staining. *P < 0.05 vs. saline-treated MI mice, n = 8. G Representative picrosirius-red–stained cardiac tissue from saline-treated and RR-11a-treated mice on day 30 post-MI or sham operation; the red staining represents collagens I and III. H–I Quantification of fibrotic areas at papillary (H) and apical (I) levels 30 days post-MI in saline-treated and RR-11a-treated mice; *P < 0.05 vs. sham-operated mice; #P < 0.05 vs. saline-treated MI mice; n = 8. J Representative polarised microscope images of picrosirius-red–staining, collagen bundles appear green or yellow (n = 8). Scale bars: white, 50 μm; black, 50 μm.

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