Fig. 2: ZD55-IL-24 therapy remodels the cytokine microenvironment of the established tumors in B16-bearing immunocompetent mouse model. | Cell Death & Disease

Fig. 2: ZD55-IL-24 therapy remodels the cytokine microenvironment of the established tumors in B16-bearing immunocompetent mouse model.

From: The armed oncolytic adenovirus ZD55-IL-24 eradicates melanoma by turning the tumor cells from the self-state into the nonself-state besides direct killing

Fig. 2

C57BL/6 mice bearing B16 tumors were treated with the regimens indicated in Fig. A. Two days after the last injection, tumors were isolated and cytokine levels were measured by cytokine antibody arrays. A Original images of cytokine antibody arrays. B Heat-map of cytokine changes in A (average signal intensity of two repeat spot) (see also Supplementary Table 1). P PBS, Z ZD55-IL-24. C The down-regulated cytokines in B. Difference scores ≤0.65 (dashed line) are considered as significant down-regulation. D The up-regulated cytokines in B. Difference scores ≥1.5 (dashed line) are considered as significant up-regulation.

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