Fig. 7: Knockout of FOXO3a in LM-3 cells subcutaneous xenograft tumors enhances the efficacy of sorafenib in nude mice. | Cell Death & Disease

Fig. 7: Knockout of FOXO3a in LM-3 cells subcutaneous xenograft tumors enhances the efficacy of sorafenib in nude mice.

From: Hypoxia induces sorafenib resistance mediated by autophagy via activating FOXO3a in hepatocellular carcinoma

Fig. 7

A, B Tumor regression rates were calculated by body weight and tumor volume of nude mice with different treatments (cells transfected with scramble shRNA (sh-NC) and FOXO3a shRNA (sh-FOXO3a); Sorafenib+sh-NC vs. Sorafenib+sh-FOXO3a, **p < 0.01, ***p < 0.001; t-test). C Representative pictures of xenograft tumors in nude mice with different treatments after 2 weeks. D Immunohistochemical assessment of expression of p62 of xenograft tumors from nude mice with different treatments (the lower panels are the amplified images of the red frames of upper panels; normal saline vs. Sorafenib, **p < 0.01, t-test; Sorafenib+sh-NC vs. Sorafenib+sh-FOXO3a, ###p < 0.001, t-test). Each experiment was performed in triplicate (N = 3). The data are presented as the means ± SD.

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