Table 2 Up and downregulated metabolic genes in CD4 T cells with >2 fold changes.
Category | Gene | Fold change |
|---|---|---|
OXPHOS | SDHB | −2.72317665 |
BAX | 2.25509595 | |
IDH2 | −3.3836822 | |
UQCFRS1 | −2.3892804 | |
NDUFA3 | −2.0965658 | |
COX11 | −2.16494835 | |
NDUFB4 | −6.04910535 | |
Glycolysis | PFKFB2 | 2.30761945 |
PFKFB4 | −2.06727665 | |
Lactate production and transporters | SLC16A4 | −2.50145315 |
SLC16A10 | −2.0563729 | |
Gluconeogenesis | GPT | 2.28088635 |
GPT2 | 2.1976123 | |
ADH5 | −2.47808485 | |
GALM | −2.0332245 | |
Glycogen metabolism | GYS2 | −2.582366 |
Hexosamine metabolism | GNPNAT1 | −2.84449395 |
Pentose phosphate pathway | RPIA | −2.2417299 |
TALDO1 | 2.4924492 | |
Glycerol/fatty acid/cholesterol synthesis | ACACB | 2.3214025 |
ACAT1 | −2.0035285 | |
ACSM3 | −2.887862 | |
GPD1L | −2.20293675 | |
Serine/ glycine/one-carbon metabolism | DNMT3B | −2.56062905 |
GCSH | −2.8607831 | |
GLDC | 2.34707975 | |
MAT2B | −2.0632765 | |
MTHFD2 | −2.7761227 | |
PSAT1 | 2.5371184 | |
TCA cycle | FH | −2.2149622 |
PDK1 | −4.4372955 | |
SDHAF1 | 2.2466182 | |
SUCLG2 | −2.4647895 | |
Glutamine transporters and glutaminolysis | SLC1A5 | 2.5634322 |
Redox balance | GCLM | 7.02115825 |
ME2 | −3.1165164 | |
Fatty acid oxidation | ACADSB | −4.23406895 |
ALDH3A2 | −2.1076536 | |
HADH | −4.00500305 | |
PAFAH1B2 | −2.0055203 | |
ACSL4 | −3.1240279 | |
Nucleotide metabolism | ADCY4 | 5.6766289 |
AK5 | −4.1834393 | |
AMPD3 | 3.6734286 | |
DCK | −2.4675163 | |
PAICS | −2.0157439 | |
PNP | −3.19877885 | |
PPAT | −2.25211545 | |
RRM1 | −2.4361025 | |
RRM2 | −2.15779715 | |
TK1 | −2.1033255 | |
TYMS | −7.74290015 | |
UPP1 | −4.65474695 | |
Mitochondrial biogenesis | TFAM | −2.80362125 |
