Fig. 1: Differential expression profiles of LncRNAs in LUAD tissues with and without lymph node metastasis.
From: Linc00426 accelerates lung adenocarcinoma progression by regulating miR-455-5p as a molecular sponge
a Distinguishable LncRNA profiling in LUAD tissues analyzed by hierarchical clustering (fold change ≥ 2; P < 0.05). Relative expression levels from high to low were indicated by red and green, respectively. b Volcano plots of LncRNAs. The red plots were differentially expressed LncRNAs with statistically significant difference (fold change ≥ 2, P < 0.05). c Variations in LncRNAs among LUAD tissues presented by scatter plots. d Relative expression of seven LncRNAs in LUAD tissues determined by RT-qPCR. Student’s t test. e Relative expression of Linc00426 in 72 LUAD tissues with lymph node metastasis and 72 LUAD tissues without lymph node metastasis determined by RT-qPCR. GAPDH serves as a reference gene for Linc00426. Results were presented as log2fold lymph node metastasis tissues relative to without lymph node metastasis. Student’s t test. f Expression of Linc00426 in different LUAD cells and BEAS-2B cells examined by RT-qPCR. One-way ANOVA. Experiments were performed three times and data were presented as mean ± SD. *P < 0.05.
