Fig. 5: Linc00426 serves as a ceRNA by sponging miR-455-5p and modulating UBE2V1.
From: Linc00426 accelerates lung adenocarcinoma progression by regulating miR-455-5p as a molecular sponge
a PPI network of targeted genes. b Hub genes of targeted genes. c–g Expression of hub genes in LUAD and normal lung tissues. h, i Kaplan–Meier plots of UBE2K and UBE2V1. j The UBE2V1 3′-UTR WT and UBE2V1 3′-UTR Mut. k The luciferase activity of transfected cells. Student’s t test. i The expression of UBE2V1 in LUAD cells and BEAS-2B cells is determined by Western blot. One-way ANOVA. m Effects of UBE2V1 on the invasive ability of A549 cells with control and siUBE2V1. Scale bar = 100 μm. Student’s t test. n Effects of miR-455-5p on protein levels of UBE2V1. Student’s t test. o Effects of sh-Linc00426 on protein levels of UBE2V1. Student’s t test. Experiments were performed three times and data were presented as mean ± SD. *P < 0.05.
