Fig. 3: TLR2 interacts with Akt-mTOR pathway and glucose metabolism.
From: Hepatitis B virus particles activate B cells through the TLR2–MyD88–mTOR axis
A Interaction network between TLR, Akt, mTOR, and glucose metabolism. B Sorting scheme for isolating naïve mouse B cells and in vitro stimulation. C Expression of Akt and p-mTOR in HBV particles/TLR2-stimulated B cells were detected by Flow cytometry and Western blotting. D Glucose and glutamine uptake in HBV particles/TLR2-L stimulated B cells was measured by detecting the MFI of the glucose analog 2-NBDGs and CD98. E Lactate production in the cell culture medium in HBV particle/TLR2-L-stimulated B cells was detected with specific kits. Data are representative of two independent experiments. All data are presented as mean ± SD (*p < 0.05; **p < 0.01; ***p < 0.001) statistical relevance was determined by one-way ANOVA.
