Fig. 1: MiR-98 participates in the acute phase of ischemic stroke. | Cell Death & Disease

Fig. 1: MiR-98 participates in the acute phase of ischemic stroke.

From: Neuronal extracellular vesicle derived miR-98 prevents salvageable neurons from microglial phagocytosis in acute ischemic stroke

Fig. 1

a–b The expression of miR-98 in the serum of acute stroke patients (both male and female) vs. healthy controls. c The expression level of miR-98 in the serum of acute stroke rats vs. sham groups. d–e The expression level of miR-98 in the core zone and penumbra field of rats after ischemic stroke from 1 day to 5 week (N = 6 rats for each group). f–h Downregulation of miR-98 expression detected by fluorescence in situ hybridization (FISH) in ipsilateral regions at 1 day and 3 day after ischemic stroke compared with contralateral regions and sham group and quantification. Scale bar = 200 μm. (N = 3 rats for each group). i–j The determination of the miR-98 expression level alterations of primary neurons treated with 30-minute OGD and reoxygenation 30 min, 1 h, 3 h, and 5 h compared with starvation treatment (removing B27). (n = 3 independent experiments). Data are means±S.E.M., n = 8 mice/group. *P, #P, $P < 0.05; **P, ##P, $$P < 0.01; and ***P, ###P < 0.001 vs. control.

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