Fig. 6: SQV improves survival and attenuates lung and extrapulmonary injury in septic mice. | Cell Death & Disease

Fig. 6: SQV improves survival and attenuates lung and extrapulmonary injury in septic mice.

From: The HIV protease inhibitor Saquinavir attenuates sepsis-induced acute lung injury and promotes M2 macrophage polarization via targeting matrix metalloproteinase-9

Fig. 6

Mice were intraperitoneally administered SQV 5, 10 mg/kg or vehicle at 0 (immediately) and 12 h after CLP. A Survival rates (n = 12 per group) were detected. Data were analyzed by Mantel–Cox test (survival). *P < 0.05 versus CLP (DMSO) group. Mice were intraperitoneally administered SQV 10 mg/kg or vehicle at 0 (immediately) and 12 h after CLP. After 24 h, samples were collected. B Hematoxylin and eosin (H&E)-stained lung sections (×200 magnification), and C Lung injury score were measured. D Lung EBA permeability, E total cell counts, and F proteins in bronchoalveolar lavage fluid (BALF) were detected from mice. Proinflammatory cytokines from G lung tissues, H BALF, and I serum were measured from mice (24 h of sham or CLP operation) with or without SQV (10 mg/kg) treatment. *P < 0.05, ***P < 0.001 versus sham groups; #P < 0.05, ##P < 0.01, ###P < 0.001 versus CLP (DMSO) group. Results in panels (B–I) are from four groups, each group has six mice. Data are represented as means ± SEM.

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