Fig. 7: Regulation of p53 expression changes renal inflammation. | Cell Death & Disease

Fig. 7: Regulation of p53 expression changes renal inflammation.

From: Snai1-induced partial epithelial–mesenchymal transition orchestrates p53–p21-mediated G2/M arrest in the progression of renal fibrosis via NF-κB-mediated inflammation

Fig. 7

A Immunohistochemistry staining and enlarged images of F4/80-positive macrophages in the interstitium of sham, UUO + vector, UUO + p53 plasmid, and UUO + p53 shRNA group and B their quantifications. Scale bar = 100 μm. C Relative mRNA expression of IL-1β, IL-6, and TNF-α in kidneys from different groups. ***P < 0.001 compared with the sham group. #P < 0.05; ##P < 0.01; ###P < 0.001 compared with the UUO + vector group.

Back to article page