Fig. 2: Downregulation of miRNA-9-5p promoted the proliferation of astrocytes and the expression of astrocyte-derived neurotrophic factors in the chronic phase after TBI.

A The immunoblotting and quantitative data of B Bcl-2, C Bax, D cleaved caspase-3, E caspase-3, F NeuN, G GAP-43, H PSD-95, I synaptotagmin, J GFAP, K Thbs-1, L Thbs-2, M BDNF, N NGF, and O VEGF were detected at 35 days after CCI (n = 5/group). (△P < 0.05, △△△P < 0.001 versus the sham group; **P < 0.01, ***P < 0.001 versus the CCI group) (CCI: control cortex impact, DI: double injection, SI: single injection). Error bars indicate mean ± SD.