Fig. 5: Downregulation of miRNA-9-5p activated the Notch pathway by promoting the expression of Thbs-2. | Cell Death & Disease

Fig. 5: Downregulation of miRNA-9-5p activated the Notch pathway by promoting the expression of Thbs-2.

From: Downregulation of microRNA-9-5p promotes synaptic remodeling in the chronic phase after traumatic brain injury

Fig. 5

A The structure of Thbs-2 protein. B Schematic diagram of the relationship among Thbs-2, Notch, and Jagged. C Immunoblotting showing the relationship between Thbs-2 and Jagged. D Immunoblotting showing the relationship between Thbs-2 and Notch. E The immunoblotting and F quantitative data of Thbs-2 bound to Jagged1 and Jagged2 (n = 4/group) (*P < 0.05, **P < 0.01 versus the Jagged1 group). G The immunoblotting and H quantitative data of Thbs-2 bound to Notch1, Notch2, Notch3, and Notch4 (n = 4/group) (*P < 0.05, **P < 0.01, ***P < 0.001 versus the Notch1 group). I The immunoblotting and J quantitative data of Hes-1 in neurons (n = 4/group) (*P < 0.05 versus the control group; ##P < 0.01 versus the ACM group; ++P < 0.01 versus the ACM (inhibitor) group) (ACM: astrocyte co-cultured model). Error bars indicate mean ± SD.

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