Fig. 4: KDM6B is involved in the development of CRPC. | Cell Death & Disease

Fig. 4: KDM6B is involved in the development of CRPC.

From: KDM6B is an androgen regulated gene and plays oncogenic roles by demethylating H3K27me3 at cyclin D1 promoter in prostate cancer

Fig. 4

A Comparison of KDM6B mRNA and protein expression between LNCaP and C42B cells. Error bars means SD, n = 3 independent repeats. B The immunochemistry results of KDM6B in normal prostate tissue, pretherapy prostate cancer tissue, and castration-resistant prostate cancer tissue are shown. C Single MDV3100 and GSK-J4 treatment failed to suppress the proliferation of pSLenti-KDM6B-transfected LNCaP cells, but the phenomenon could be terminated by the combination of MDV3100 plus GSK-J4. Error bars means SD, n = 3 independent repeats. D Combination of MDV3100 plus GSK-J4 was effective for CRPC C42B cells and MDV3100-resistant CRPC MDVR cells. Error bars mean SD, n = 3 independent repeats (ns: not significant, *p < 0.05, **p < 0.01; MDV3100, enzalutamide; DMSO, dimethylsulfoxide).

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