Fig. 3: DDX39B promotes CRC metastasis in vivo and EMT.
From: The DDX39B/FUT3/TGFβR-I axis promotes tumor metastasis and EMT in colorectal cancer
A HE staining of CRC orthotopic transplantation tumor and spleen metastasis in SW480/Scramble and SW480/shDDX39B groups. Spleen metastatic numbers were compared between these groups; error bars, SD; scale bars, 20/50/200 μm. B EMT marker genes and MMP expression in SW480 cells with DDX39B overexpression and knockdown. C Cytoskeleton in SW480 cells with DDX39B overexpression and knockdown, assessed by FITC-phalloidin staining; scale bars, 20 μm. D IHC and IF of orthotopic transplantation tumor in mice. E-cadherin, Vimentin, and MMP9 expression levels were compared between SW480/Scramble and SW480/shDDX39B groups; scale bars, 20 μm. Relevant pathological scores of each were also obtained; error bars, SD.
