Fig. 6: DDX39B enhances the invasive property of CRC cell via FUT3-induced L-fucosylation of TGFβR-I and then activation of the TGFβ/SMAD signaling pathway.
From: The DDX39B/FUT3/TGFβR-I axis promotes tumor metastasis and EMT in colorectal cancer
A Total and fucosylated TGFβR-I (AAL) expression in SW480 cells with DDX39B overexpression and silencing; scale bars, 20 μm. B Targeted genes of the TGFβ signaling pathway and FUT3 expression in SW480 cells with DDX39B overexpression and silencing (nuclear and cytoplasmic separation assay). C Targeted genes of the TGFβ signaling pathway and EMT biomarker expressions in SW480/Vector and SW480/DDX39B cells with SB431542 (0/20 μM) treated. D Migration and invasion abilities in SW480/Vector and SW480/DDX39B cells with SB431542 treated (Transwell assay); error bars, SD; scale bars, 100 μm.
