Fig. 7: The DDX39B–FUT3–TGFβR-I axis promotes CRC metastasis and EMT.
From: The DDX39B/FUT3/TGFβR-I axis promotes tumor metastasis and EMT in colorectal cancer
A Targeted genes of the TGFβ signaling pathway, EMT biomarkers and FUT3 expression in SW480/Scramble and SW480/shDDX39B cells with TGFβ1 treated (10 ng/ml). B E-cadherin and Vimentin expression in SW480/Scramble and SW480/shDDX39B cells with TGFβ1 treated were detected using IF; scale bars, 50 μm. C Migration and invasion abilities in SW480/Scramble and SW480/shDDX39B cells with TGFβ1 treated (Transwell assay); error bars, SD. D Targeted genes of TGFβ signaling pathway, EMT marker genes and FUT3 expression in SW480/Vector and SW480/DDX39B cells with FUT3 silencing. E Migration and invasion abilities in SW480/Vector and SW480/DDX39B cells with FUT3 knockdown (Transwell assay); error bars, SD. F Hypothesized molecular mechanism of DDX39B in the development of CRC.
