Fig. 2: Gained mutations and amplification of chromosome segments were detected in CYH33-resistant cells. | Cell Death & Disease

Fig. 2: Gained mutations and amplification of chromosome segments were detected in CYH33-resistant cells.

From: Adaptive resistance to PI3Kα-selective inhibitor CYH33 is mediated by genomic and transcriptomic alterations in ESCC cells

Fig. 2

Genomic DNA purified from KYSE70C, KYSE180C, KYSE410C, and KYSE510C cells and their parental cells was subjected to whole-genome sequencing. A Number of non-synonymous mutations and representative mutations in KYSE70C, KYSE180C, KYSE410C, and KYSE510C cells compared to their parental counterparts. B Amplified chromosome segments in KYSE180C, KYSE410C, and KYSE510C cells compared to parental cells.

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