Fig. 2: Cisplatin addition to axons is sufficient to induce localized axon degeneration. | Cell Death & Disease

Fig. 2: Cisplatin addition to axons is sufficient to induce localized axon degeneration.

From: p53 is required for nuclear but not mitochondrial DNA damage-induced degeneration

Fig. 2

A Neurons in microfluidic chambers were left untreated (UNT; Top panels) or had their axons alone (and not their soma/nucleus) exposed to cisplatin (Axonal Cisplatin; 20 μM; Bottom panels) for 120 h and stained for tubulin. The scale bar represents 20 μm. Representative images are shown from n = 3. B Quantification of the axon degeneration from these experiments is shown on the right (n = 8), individual data points and mean are depicted. Paired t-test (two-tailed) (*p < 0.05).

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