Fig. 2: Proteomics analysis of the response to hypoxia–reoxygenation.

A Hierarchical clustering of the complete proteomics dataset. 12H 12 h of hypoxia, 30 R 30 min of reoxygenation, 120 R 120 min of reoxygenation. B Volcano plots for experimental conditions 12H, 30R, and 120R compared to Ctrl in crypt-like and villus-like hSIOs, in which abundance ratio (Log2) is plotted against the p-value (−log10). The number upregulated (▲) and downregulated (▼) proteins are indicated in every plot (adjusted p-value < 0.05). On/off proteins are not shown and can be found in Table S2. N = 6 from 3 hSIO lines.