Fig. 1: α-MGT exhibits potent growth inhibition in HCC cells in vitro. | Cell Death & Disease

Fig. 1: α-MGT exhibits potent growth inhibition in HCC cells in vitro.

From: Anticancer activity of dietary xanthone α-mangostin against hepatocellular carcinoma by inhibition of STAT3 signaling via stabilization of SHP1

Fig. 1

a Chemical structure of α-MGT. b–e Human HCC cells (5000 cells/well) were treated with a series of concentrations of α-MGT for the indicated times, respectively. The cell growth was then detected by SRB staining. f SK-Hep-1 cells were treated with the indicated concentrations of sorafenib for 48 h without or with α-MGT (2 μM). HepG2 and SK-Hep-1 cells (1000 cells/well) were treated with α-MGT for 24 h, and then incubated for additional 14 days. The numbers of clones were measured by crystal violet staining. Representative images (g) and quantitative results (h) of colony formation were presented. Data are expressed as mean ± SD, n = 3. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001 vs. vehicle control.

Back to article page