Fig. 7: α-MGT suppresses HepG2 and SK-Hep-1 xenograft tumor growth in nude mice. | Cell Death & Disease

Fig. 7: α-MGT suppresses HepG2 and SK-Hep-1 xenograft tumor growth in nude mice.

From: Anticancer activity of dietary xanthone α-mangostin against hepatocellular carcinoma by inhibition of STAT3 signaling via stabilization of SHP1

Fig. 7

The nude mice bearing HepG2 or SK-Hep-1 cells were intraperitoneally administered vehicle or α-MGT (50 mg/kg) for 20 days. The tumor volumes (a–d) and tumor weights (e) were measured. The expressions of Ki67 (e, i), Bcl2 (f, j), pTyr705-STAT3 (g, k), and SHP1 (h, l) in tumor tissues were evaluated by IHC method. Bar = 100 μm. Data are expressed as mean ± SD, n = 5. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001 vs. vehicle control.

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