Fig. 5: ATG5 is a direct target of miR-567 in breast cancer. | Cell Death & Disease

Fig. 5: ATG5 is a direct target of miR-567 in breast cancer.

From: RETRACTED ARTICLE: Exosome-transmitted miR-567 reverses trastuzumab resistance by inhibiting ATG5 in breast cancer

Fig. 5

a Schematic of the hypothetical duplexes formed by miR-567 and the 3′-UTR of ATG5. b Relative luciferase activity in cells transfected with the miR-567 mimic were determined, *P < 0.05, **P < 0.01 compared with control mimics. c ATG5 expression was shown via western blotting in trastuzumab-resistant or parental cells. d, e ATG5 transcript and protein levels were detected by qRT-PCR and western blotting, respectively; P < 0.01 compared with control groups. f ATG5 mRNA level was identified in primary breast cancer tissues from patients responding or resistant to trastuzumab treatment. g Spearman’s correlation test was performed to verify the association between miR-567 and ATG5 mRNA expression. *P < 0.05, **P < 0.01.

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