Fig. 4: KIKO mice have reduced cold tolerance.
From: Frataxin deficiency induces lipid accumulation and affects thermogenesis in brown adipose tissue
a Body temperature measured in 6-month-old mice after 12 h cold exposure (n = 6 each group; *p < 0.05, **p < 0.01). b Representative histology images of BAT from mice exposed to cold after staining with H&E (n = 3 each group). Scale bars, 25 μm. c Lipid droplets (LDs) diameter measurement in three fields for each BAT histology through ImageJ (300 droplets total at least for each sample). BAT of WT and KIKO mice at RT (see c) or exposed to cold b for 12 h were analyzed (n = 3, ****p < 0.0001 vs. RT, **p < 0.001 vs. WT mice at RT, °°p < 0.001 vs. WT mice at 4 °C).
