Fig. 6: The expression of genes related to mitochondrial respiration, thermogenesis, and lipolytic pathways are altered in BAT of KIKO mice.
From: Frataxin deficiency induces lipid accumulation and affects thermogenesis in brown adipose tissue
a, b RT-qPCR analysis of mitochondrial genes a and genes related to lipid metabolism b in BAT of 6-month-old mice (n = 6; *p < 0.05, **p < 0.01, ***p < 0.001 vs. WT; °p < 0.05, °°p < 0.01, °°°p < 0.001 vs. KIKO; ##p < 0.01, ###p < 0.001 vs. WT at 4 °C). c, d Representative immunohistochemical analyses of phospho-PKA substrates c and perilipin-1 d (n = 3 mice each group). Black arrows c indicate some nuclei showing positivity to the immunostaining of phospho-PKA substrates.
