Fig. 8: miR-210-5p accelerates xenograft tumor growth and pulmonary metastasis in vivo. | Cell Death & Disease

Fig. 8: miR-210-5p accelerates xenograft tumor growth and pulmonary metastasis in vivo.

From: miR-210-5p promotes epithelial–mesenchymal transition by inhibiting PIK3R5 thereby activating oncogenic autophagy in osteosarcoma cells

Fig. 8

a Images of tumors obtained from mice treated with LV-miR-210-5p and ANTI-miR-210-5p and their negative controls; n = 6 mice/group. b, c Tumor volume and weight were calculated. d, e Western blot and immunohistochemical analysis were performed to evaluate PIK3R5 expression in vivo. Scale bar = 100 μm. f Representative images of pulmonary metastases were obtained by the IVIS imaging system. g Representative H&E-stained lung sections from mice in different groups. Scale bar = 200 μm. h, i Immunohistochemical staining of ATG5 and vimentin in xenograft tumors. Scale bar = 100 μm.

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