Fig. 7: A model for how Pten deletion or inhibition promotes ESC pluripotency.
From: Pten-mediated Gsk3β modulates the naïve pluripotency maintenance in embryonic stem cells
Pten deletion or inhibition promotes naïve pluripotency of mouse ESCs by activating Akt and further suppressing Gsk3β. In addition, the Pten/Akt/mTOR signaling pathway is also involved in regulating ESC maintenance.
