Fig. 5: Quantitative analysis of primary tumor and serum metabolites from SKBR3FLAG-KISS1R and SKBR3pFLAG control orthotopic xenografts.

a Volcano plot comparing metabolite levels measured by LC–MS in primary tumors of SKBR3FLAG-KISS1R xenografts versus those of SKBR3pFLAG controls. The fold change between the two groups and p values for each metabolite are plotted and represented in a bar graph (Supplementary Fig. 3b). Fold changes >1 and <1 indicate increases and decreases, respectively, in metabolite levels in SKBR3FLAG-KISS1R and control tumor groups. Student’s two-tailed t test, *p < 0.05. Metabolites in serum: b inositol, c glycerophosphocholine, d cysteine, e valine, and f leucine.