Fig. 2: Manual scoring confirms association of low Bak, Bax and Smac protein expression with improved PFS. | Cell Death & Disease

Fig. 2: Manual scoring confirms association of low Bak, Bax and Smac protein expression with improved PFS.

From: Low expression of pro-apoptotic proteins Bax, Bak and Smac indicates prolonged progression-free survival in chemotherapy-treated metastatic melanoma

Fig. 2

a Correlation between automated and manual H scores. Manual scores were obtained from two independent pathologists blinded to patient follow-up. Correlation was analysed using Spearman’s rank correlation coefficient. b Median H scores were used as cutoff to separate the patients with high (red line) and low (blue line) expression of each protein. Log-rank test was used to compare the Kaplan–Meier curves for progression-free survival from the date of sample procurement.

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