Fig. 4: Iron chelator inhibits APAP-induced hepatotoxicity and lipid peroxidation. | Cell Death & Disease

Fig. 4: Iron chelator inhibits APAP-induced hepatotoxicity and lipid peroxidation.

From: Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure

Fig. 4

Liver and serum samples were obtained from mice injected with vehicle or APAP (200 mg/kg) 3 h after injection. Mice were treated with DFO (100 mg/kg/day) or vehicle for 7 consecutive days prior to APAP injection. a Serum AST and ALT levels. b, c HE staining and histopathology score. d Hepatic CYP2E1 mRNA expression. e Immunostaining for 4-HNE. f Hepatic PTGS2 mRNA expression. g Hepatic MDA levels. h Hepatic GSH levels. Statistical significance was calculated using the Mann–Whitney test c–e with the Bonferroni correction. Data are expressed as dot plots and/or means ± SEM (n = 6–8 for each). *p < 0.05, **p < 0.01.

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