Fig. 8: Role of circRACGAP1 in mediating autophagy and apatinib sensitivity. | Cell Death & Disease

Fig. 8: Role of circRACGAP1 in mediating autophagy and apatinib sensitivity.

From: Silencing of circRACGAP1 sensitizes gastric cancer cells to apatinib via modulating autophagy by targeting miR-3657 and ATG7

Fig. 8

a Immunohistochemical staining of ATG7, LC3-II, and SQSTM1 in the tumor xenograft tissues from the apatinib and control groups. Bar scale, 100 μm. b Correlation analysis of relative ATG7 expression and relative circRACGAP1 expression (left), relative ATG7 expression and relative miR-3657 expression (middle), and relative circRACGAP1 expression and relative miR-3657 expression (right) in ten gastric cancer tissues. c Schematic diagram of the relationship among apatinib, the circRACGAP1-miR-3657-ATG7 axis, autophagy and apoptosis in GC. Left: apatinib induces autophagy via the circRACGAP1-miR-3657-ATG7 axis. Right: knockdown of circRACGAP1 promotes the antitumor activity of apatinib via inhibition of autophagy.

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