Fig. 5: CZ enhances immunosuppressive ability of MSCs by inhibiting FOXO3 phosphorylation. | Cell Death & Disease

Fig. 5: CZ enhances immunosuppressive ability of MSCs by inhibiting FOXO3 phosphorylation.

From: Chlorzoxazone, a small molecule drug, augments immunosuppressive capacity of mesenchymal stem cells via modulation of FOXO3 phosphorylation

Fig. 5

a, b Representative flow cytometry analysis of T-cell activation marker CD69 and CD25 (up) and statistical histogram of CD69 and CD25 expression on T cells (down) in different culture groups. c MTS assay of T cells proliferation in different culture groups for 4 days. d Histogram of quantitative RT-PCR of gene expression of IDO and selected cytokines and chemokines secreted by MSCs altered by different CZ and/or different kinase inhibitors or activators. *P < 0.05, **P < 0.01, ***P < 0.001, ns no significant difference.

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