Fig. 7: Knockdown of CircHIPK3 or LncGAS5 alleviates nasal symptoms of AR mice via miR-495/GATA-3 pathway. | Cell Death & Disease

Fig. 7: Knockdown of CircHIPK3 or LncGAS5 alleviates nasal symptoms of AR mice via miR-495/GATA-3 pathway.

From: The regulatory network among CircHIPK3, LncGAS5, and miR-495 promotes Th2 differentiation in allergic rhinitis

Fig. 7

a AR-induced mice were treated intranasally with CircHIPK3/LncGAS5-knockdown lentivirus, or together with miR-495 inhibitor (n = 6 in each group). The H&E staining of nasal mucosa (Scale bar = 10 μm), the number of sneezes and nasal rubbings, and the levels of IgE and IL-4 in serum and nasal mucosa were shown. b AR-induced mice were treated intranasally with CircHIPK3/LncGAS5-knockdown lentivirus, or together with GATA-3-overexpressing lentivirus (n = 6 in each group). The H&E staining of the nasal mucosa (Scale bar = 10 μm), the number of sneezes and nasal rubbings, and the levels of IgE and IL-4 in serum and nasal mucosa were shown. *p < 0.05, **p < 0.01 vs AR + lenti-GFP + NC or AR + lenti-GFP. #p < 0.05 vs AR + Lenti-siCircHIPK3/Lenti-siLncGAS5 + NC or AR + Lenti-siCircHIPK3/Lenti-siLncGAS5.

Back to article page