Fig. 6: Pharmacological inhibition of CD73 adenosinergic signaling induces RICS dysfunction.
From: CD73 promotes tumor metastasis by modulating RICS/RhoA signaling and EMT in gastric cancer
a WB analysis of phosphorylation level of RhoA/LIMK/coflin signaling in MKN45 cells treated with APCP or siCD73, and AGS cells transfected with CD73 plasmids. Relative gray value was shown (mean ± SD, n = 3, one-way ANOVA). b WB analysis of inhibition effects of CD73 plasmids, adenosine receptor agonist (CGS21680, NECA), or adenosine in RhoA/LIMK/cofilin signaling. C WB analysis of phosphorylation level of RhoA/LIMK/coflin signaling to determine rescued function of adenosine receptor agonist or adenosine in MKN45 cells transfected with siCD73. *p < 0.05, ***p < 0.001, and N.S., non-significant.
