Fig. 7: CR enhances LTP in CA3–CA1 synapses. | Cell Death & Disease

Fig. 7: CR enhances LTP in CA3–CA1 synapses.

From: Caloric restriction triggers morphofunctional remodeling of astrocytes and enhances synaptic plasticity in the mouse hippocampus

Fig. 7

Input–output relationships of PrV amplitude —stimulation current (Istim) (a) and fEPSP amplitude—Istim (b). c LTP induced by HFS in the CA1 region of the hippocampus of control (gray squares) and CR (green circles) mice. Inset, sample fEPSPs before HFS (dark color) and 40 min after HFS (light color). Gray—control (Ctrl), green—CR. d The summary graph is showing the mean magnitude of LTP 40–50 min after HFS. e Same as (c) but in the presence of NR2B-NMDARs blocker Ro25-6981. f Same as (d) but in the presence of NR2B-NMDARs blocker Ro25-6981. The data are presented as mean ± SEM; NS. p > 0.05; *p < 0.05; two-sample t-test.

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