Fig. 2: Overexpression of HOTAIRM1 inhibited tumor growth in vitro and in vivo. | Cell Death & Disease

Fig. 2: Overexpression of HOTAIRM1 inhibited tumor growth in vitro and in vivo.

From: RETRACTED ARTICLE: The HOTAIRM1/miR-107/TDG axis regulates papillary thyroid cancer cell proliferation and invasion

Fig. 2

a High levels of HOTAIRM1 expression in B-CPAP and TPC-1 cells, achieved by transfection with pcDNA3.1-HOTAIRM1, were measured by qRT-PCR (n = 3, **p < 0.001). b, c The effect of HOTAIRM1 on PTC cell proliferation determined by CCK-8 and colony-formation assay (n = 3, **p < 0.001); d Apoptosis was evaluated by flow cytometry (n = 3, **p < 0.001). e The tumor growth curve of xenograft tumors formed from B-CPAP cells, with or without HOTAIRM1 overexpression, in the indicated week (n = 5, **p < 0.001). f Photographs of xenograft tumors after sacrifice. g The weight of xenograft tumors after sacrifice (n = 5, **p < 0.001). h Expression of HOTAIRM1 in xenograft tumors, assessed by qRT-PCR (n = 5, **p < 0.001). i Representative photographs of immunohistochemical staining of Ki-67 in xenograft tumors. Scale bar: 50 μm.

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