Fig. 4: Effects of UC-MSCs on regulating the expression of mitophagy-related proteins in the liver of mice with I/R injury. | Cell Death & Disease

Fig. 4: Effects of UC-MSCs on regulating the expression of mitophagy-related proteins in the liver of mice with I/R injury.

From: MSCs ameliorate hepatocellular apoptosis mediated by PINK1-dependent mitophagy in liver ischemia/reperfusion injury through AMPKα activation

Fig. 4

a–c IHC of liver sections (magnification ×400) from mice with I/R injury treated with UC-MSCs or PBS and killed at 6 and 24 h after reperfusion were stained with TOM20 (column 1), Parkin (column 2) and PINK1 (column 3) antibody. The IHC staining of PINK1, Parkin and TOM20 in liver tissues was semiquantified (n = 5/group). d The expression of Parkin, PINK1 and TOM20 in liver tissues was determined by western blotting, and the average intensities of the bands in the western blot were quantified (n = 5/group). The data are presented as the means ± SEMs. *p < 0.05, **p < 0.01, ***p < 0.001 (all p-values were obtained by one-way ANOVA).

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