Fig. 6: Inhibiting the expression of circGCN1L1 in a TMJOA rat model slows the progression of osteoarthritis. | Cell Death & Disease

Fig. 6: Inhibiting the expression of circGCN1L1 in a TMJOA rat model slows the progression of osteoarthritis.

From: CircGCN1L1 promotes synoviocyte proliferation and chondrocyte apoptosis by targeting miR-330-3p and TNF-α in TMJ osteoarthritis

Fig. 6

a, b HE and Safranin-O/Fast green staining of the cartilage in control and occlusion-induced OA rats with shcircGCN1L or shcircGCN1L1 MT injected. Scale bar, 50 μm. OARSI scoring was performed according to the staining results; N = 40 (10 rats in each group). *p < 0.05. c, d IHC staining in control and occlusion-induced OA rats with shcircGCN1L or shcircGCN1L1 MT injected. Scale bar, 50 μm. N = 40 (10 rats in each group). *p < 0.05. Data are presented as mean ± S.D. One-way ANOVA with Bonferroni test was performed. HE hematoxylin–eosin, IHC immunohistochemistry, MT mutant, OA osteoarthritis, OARSI Osteoarthritis Research Society International.

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