Table 1 Correlation analysis between ZNF750 genotypes in 612 ESCC samples and clinicopathological variables.
Clinical, epidemiological or pathological feature | ZNF750_mut | Proportion | ZNF750_wt | Proportion | P value | ZNF750_mut |
|---|---|---|---|---|---|---|
All cases | 612 | 48 | 7.84% | 564 | 92.16% | Â |
Age | ||||||
 <60 | 270 | 23 | 8.52% | 247 | 91.48% |  |
 60–69 | 264 | 17 | 6.44% | 247 | 93.56% | 0.457 |
 ≥70 | 78 | 8 | 10.26% | 70 | 89.74% |  |
Sex | ||||||
 Male | 439 | 39 | 8.88% | 400 | 91.12% | 0.137 |
 Female | 173 | 9 | 5.20% | 164 | 94.80% |  |
Tobacco use | ||||||
 No | 262 | 17 | 6.49% | 245 | 93.51% | 0.293 |
 Yes | 350 | 31 | 8.86% | 319 | 91.14% |  |
Alcohol consumption | ||||||
 No | 391 | 27 | 6.91% | 364 | 93.09% | 0.274 |
 Yes | 221 | 21 | 9.50% | 200 | 90.50% |  |
Tumor location | ||||||
 Upper thoracic | 198 | 3 | 1.52% | 195 | 98.48% |  |
 Middle thoracic | 364 | 22 | 6.04% | 342 | 93.96% | 3.1427E-16 |
 Lower thoracic | 50 | 23 | 46.00% | 27 | 54.00% |  |
Histological grade | ||||||
 Grade 1 | 71 | 3 | 4.23% | 68 | 95.77% | 0.145 |
 Grade 2 | 402 | 29 | 7.21% | 373 | 92.79% | 0.145 |
 Grade 3 | 139 | 16 | 11.51% | 123 | 88.49% |  |
Pathologic Stage | ||||||
 I&II | 374 | 16 | 4.28% | 358 | 95.72% | 8E-05 |
 III&IV | 238 | 32 | 13.45% | 206 | 86.55% |  |
Pathologic T Stage | ||||||
 T1 | 47 | 4 | 8.51% | 43 | 91.49% |  |
 T2 | 213 | 13 | 6.10% | 200 | 93.90% | 0.003 |
 T3 | 341 | 26 | 7.62% | 315 | 92.38% |  |
 T4 | 11 | 5 | 45.45% | 6 | 54.55% |  |
Pathologic N Stage | ||||||
 N0 | 355 | 16 | 4.51% | 339 | 95.49% |  |
 N1 | 147 | 15 | 10.20% | 132 | 89.80% | 0.001 |
 N2 | 79 | 13 | 16.46% | 66 | 83.54% |  |
 N3 | 31 | 4 | 12.90% | 27 | 87.10% |  |
Lymphatic metastasis | ||||||
 Yes | 257 | 33 | 12.84% | 224 | 87.16% | 0.0001 |
 No | 355 | 15 | 4.23% | 340 | 95.77% |  |
Prognosis (Log-rank Mantel-Cox test) | ||||||
 Dead | 263 | 29 | 11.03% | 234 | 88.97% |  |
 Survival | 324 | 17 | 5.25% | 307 | 94.75% | 0.026 |
 Missing | 25 | 2 | 8.00% | 23 | 92.00% |  |
