Fig. 1: Primary MM cells are mainly MCL1 dependent without influence of 1q gain. | Cell Death & Disease

Fig. 1: Primary MM cells are mainly MCL1 dependent without influence of 1q gain.

From: Dual targeting of BCL2 and MCL1 rescues myeloma cells resistant to BCL2 and MCL1 inhibitors associated with the formation of BAX/BAK hetero-complexes

Fig. 1

Data clustering as assessed by k-means is shown for MCL1 and BCL2 inhibitors induced cell death in 60 patients (n = 1000 initiations of algorithm). a Clusters for MCL1 inhibitor response (S63845 12.5, 25 and 50 nM) with increasing sensitivity from 1 to 4. b Patient distribution according to disease status for MCL1 sensitivity clustering. Statistical analysis was done using Fisher’s exact test. c Clusters for BCL2 inhibitor response (venetoclax 100, 300, and 1000 nM) with increasing sensitivity from 1 to 3. d Patient distribution according to disease status for BCL2 sensitivity clustering. e Primary MM cells sensitivity to MCL1 inhibitor S63845 (50 nM) according to 1q gain (n = 27). 1q amplification was detected by FISH analysis. Statistical analysis was done using Mann–Whitney test, p = 0.64.

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