Fig. 1: ICC could originate from hepatocytes.
From: Oncogenic driver genes and tumor microenvironment determine the type of liver cancer

a Immunohistochemical staining (IHC) showed that some scattered HA-tag strongly positive hepatocytes were detected in AKT/NICD-injected livers after 7 days. b IHC results showed that HA-tag protein was also expressed in ICC tissues after 4 weeks. c IHC results showed that some HA-stained hepatocytes and biliary duct cells appeared after 2 weeks. ICC: intrahepatic cholangiocarcinoma (scale bars, 50 μm).