Fig. 1: Microarray revealed that circ5615 was upregulated in CRC.
From: circ5615 functions as a ceRNA to promote colorectal cancer progression by upregulating TNKS
a Heat map of differentially expressed circRNAs between 5 CRC tissues and adjacent nontumor tissues. Gene expression in z score-transformed value was shown. b Pie chart showing dysregulated circRNAs derived from different genomic regions. c Length distribution of the dysregulated circRNAs. d The PCR analysis validated that circ5615 resisted to RNase R, while corresponding linear NFATC3 mRNA could be digested by RNase R. e Expression of circ5615 in 35 paired CRC samples were detected by RT-PCR. ACTB was used as a loading control. T tumor tissue, N nontumorous tissue. Data are shown as mean ± SD. *p < 0.05; ***p < 0.001, paired t-test.
