Fig. 7: circ5615 promoted tumor growth in vivo.
From: circ5615 functions as a ceRNA to promote colorectal cancer progression by upregulating TNKS
a Xenograft tumor models revealed that tumors grown with circ5615 knockdown were smaller than the control group. b Serial sections and IHC staining of TNKS, β-catenin, CCND1, and Ki67. c, d The volume (c) and weight (d) of subcutaneous xenograft tumors from nude mice. e Xenograft tumor models showed that circ5615 significantly promoted tumor growth. f, g The volume (f) and weight (g) of subcutaneous xenograft tumors after overexpression of circ5615. h Hypothesis diagram showed function and mechanism of circ5615 in CRC progress. Data are shown as mean ± SD (n = 6). In c, d, f, g, center line: median of data; Bounds of box: the second quartile to the third quartile; Whisker: minimum value to maximum value. *p < 0.05; ***p < 0.001, paired t-test.
