Fig. 5: HDAC7 promotes NPC cell proliferation, migration, and invasion by upregulating EphA2.
From: HDAC7 promotes the oncogenicity of nasopharyngeal carcinoma cells by miR-4465-EphA2 signaling axis
a Western blot showing the levels of EphA2 in the shHDAC7 HK1 and 5–8F cells transfected with EphA2 expression plasmid and their control cells. b–f Restoration of EphA2 expression antagonized the inhibitory effects of HDAC7 knockdown on NPC cell proliferation, and migration and invasion in vitro. CCK-8 (b), plate clone formation (c), and EdU incorporation (d) assay showing the proliferation of shHDAC7 HK1 and 5–8F cells transfected with EphA2 expression plasmid and their control cells. e Scratch wound healing showing the migration of shHDAC7 HK1 and 5–8F cells transfected with EphA2 expression plasmid and their control cells. f Transwell Matrigel invasion assay showing the invasion of shHDAC7 HK1 and 5–8F cells transfected with EphA2 expression plasmid and their control cells. Means, SDs, and statistical significance are denoted; **P < 0.01; ***P < 0.001; ns no significance.
