Fig. 8: EV-derived miR-21 promoted neuronal survival after SAH through the PTEN/Akt signaling pathway. | Cell Death & Disease

Fig. 8: EV-derived miR-21 promoted neuronal survival after SAH through the PTEN/Akt signaling pathway.

From: Extracellular vesicle-mediated transfer of miR-21-5p from mesenchymal stromal cells to neurons alleviates early brain injury to improve cognitive function via the PTEN/Akt pathway after subarachnoid hemorrhage

Fig. 8

a Hematoxylin and eosin (HE) staining of the prefrontal cortex 48 h after SAH (n = 3). b Neurological behavior scores in each group (n = 6). c Double immunofluorescence staining of cleaved-caspase-3 and NeuN in the prefrontal cortex 48 h after SAH. d TUNEL staining. e Western blot. f The protein level of phospho-Akt was normalized to total Akt protein level and BCL2, BAX, and cleaved-caspase3 was normalized to that of GAPDH.

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