Fig. 7: Treatment with 2-Cl-IB-MECA attenuates the impairment in axonal transport induced by OHT. | Cell Death & Disease

Fig. 7: Treatment with 2-Cl-IB-MECA attenuates the impairment in axonal transport induced by OHT.

From: Activation of adenosine A3 receptor protects retinal ganglion cells from degeneration induced by ocular hypertension

Fig. 7

Saline (5 µl) or 2-Cl-IB-MECA (5 µl, 1.2 µM) was administered by intravitreal injection immediately after laser-induced OHT. a Retrograde axonal transport was assessed after FG application in the superior colliculus (SCi) at 24 h after OHT induction. Representative isodensity maps generated from whole-mount preparations from 2-Cl-IB-MECA, and saline-treated OHT and contralateral retinas labeled with FG. b The total number of FG+ cells was automatically quantified from 5–6 independent experiments. ++p < 0.01, +++p < 0.001 significantly different from naïve; and ***p < 0.001 significantly different from contralateral eye.

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