Fig. 8: MDM2 is required for HJURP-induced malignant behaviors in PDAC. | Cell Death & Disease

Fig. 8: MDM2 is required for HJURP-induced malignant behaviors in PDAC.

From: Holliday junction recognition protein promotes pancreatic cancer growth and metastasis via modulation of the MDM2/p53 signaling

Fig. 8

a, b Immunoblotting of HJURP, MDM2 (a), and proteins involved in p53 signaling pathways (b) with Capan-2 cells expressing HJURP insert as well shRNAs that target MDM2. (c–i) MTT (c), sphere formation (d) and its quantification (e), migration (f) and its quantification (g), and invasion (h) and its quantification (i) of BXPC-3 cells described above. All experiments were repeated at least three times, and representative data are shown. Scale bars, 100 μm (d) and 20 μm (f, h); data are means ± SEM; **p < 0.01.

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