Fig. 3: Basic functional properties of CA3–CA1 synapses and effects of kainic acid administration in WT and pGFAP-BDNF mice. | Cell Death & Disease

Fig. 3: Basic functional properties of CA3–CA1 synapses and effects of kainic acid administration in WT and pGFAP-BDNF mice.

From: Astrocytic BDNF and TrkB regulate severity and neuronal activity in mouse models of temporal lobe epilepsy

Fig. 3

a Input/output curves evoked in a new cohort of WT and pGFAP-BDNF mice that did not received the lithium-pilocarpine treatment. Note that the pGFAP-BDNF group reached significantly larger fEPSP slopes for high (<0.3 mA) stimulus intensities. *p < 0.05. b fEPSP facilitation evoked at the hippocampal CA1 area by paired-pulse stimulation of ipsilateral Schaffer collaterals at increasing interstimulus intervals. Note the significant (*p = 0.003) increase in paired-pulse facilitation at 40 ms of interstimulus interval in pGFAP-BDNF mice. c A diagram illustrating the experimental design for the kainic acid test. d, e Representative examples of spontaneous and train-evoked seizures collected from WT (d) and pGFAP-BDNF (e) mice. Note the different duration of tonic seizures presented by the two groups of animals. f Percentage of animals presenting seizures following kainate injection. g Mean duration of tonic seizures recorded in WT and pGFAP-BDNF mice. *p = 0.003. h, i Representative examples of fEPSPs evoked at hippocampal CA3–CA1 synapses and collected from WT (h) and pGFAP-BDNF (i) mice before and after kainic acid injection. Note that the presence of tonic seizures decreased in the amplitude of the evoked fEPSP in the pGFAP-BDNF mouse.

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