Fig. 5: TDO2 is upregulated in HCC tissues and is correlated with progression and poor prognosis. | Cell Death & Disease

Fig. 5: TDO2 is upregulated in HCC tissues and is correlated with progression and poor prognosis.

From: Circular RNA circZNF566 promotes hepatocellular carcinoma progression by sponging miR-4738-3p and regulating TDO2 expression

Fig. 5

a, b High TDO2 expression in HCC tissues as indicated by IHC. Low TDO2 expression in normal adjacent tissues as indicated by IHC. c–e Kaplan–Meier analysis with log-rank testing of survival was performed in HCC patients with different TDO2 expression levels (c), differentiation in early UICC stage (I–II) and advanced UICC stage (III–IV) (d), and with or without relapse (e). f, g Western blot analysis and qRT-PCR were used to detect TDO2 protein expression in six representative paired HCC tissue specimens. h Staining scores of TDO2 expression in 57 pairs of fresh frozen HCC and matched nontumor tissues. All data are from three independent experiments and are presented as the means ± SEM or representative of three independent experiments with similar results (*p < 0.05, **p < 0.01, ***p < 0.001).

Back to article page